Ketcher 2.25.0

What’s Changed

Here are the updated release notes with links to the corresponding issues:

New features

  • #4884 – Implement basic preview display for monomer bonds

  • #4554 – Support ambiguous monomers in Ketcher (flex mode)

  • #5186 – Add ambiguous monomers to the library and allow their addition to the canvas

  • #4556 – Support of ambiguous monomers in sequence view

  • #4557 – Support of ambiguous monomers in small molecules mode

  • #4872 – New approach and UI for switching between types in sequence mode

  • #4555 – Preview for ambiguous monomers

  • #5224 – Implement basic preview in connection modal for ambiguous monomer

  • #4861 – Introducing multi-tail arrows

  • #4985 – Support retrosynthetic arrows

  • #4853 – Search monomer in library by IDT

  • #4926 – Add IDT alias to chem monomer

  • #5244 – Add CHEMs to the library

  • #5264 – Add amino acids to the library

  • #5152 – Add new settings for ACS style

  • #5560 – Update Indigo to 1.24.0 in browser module

Bugfixes and improvements

  • #5200 – The users choice is not saved in the settings but is recalculated in px

  • #4658 – Some bonds remain selected on export to SVG in Snake mode

  • #5201 – it is not possible to enter a value when selecting cm inch pt manually in the settings

  • #5454 – Export of variant monomers to Sequence/FASTA doesn’t work for presets

  • #5425 – Undo-Redo operations over ambiguous monomer causes broken canvas

  • #5464 – Undo operation removes ambiguous monomer from the canvas but keep in the KET file export

  • #5209 – Cancel of Edit Connection points dialog cause existed connection points eliminated

  • #5453 – Circle with monomer number should be few pixels down

  • #5427 – Preview tooltip for mixture ambiguous monomer shows wrong percentages

  • #5466 – HELM inline SMILES monomer canvas color is wrong

  • #5470 – Export of different mixed and alternatives peptides (with different proportions and percents) works wrong

  • #5313 – Creation preset without phosphate causes R3-less sugars disabled in the library

  • #5447 – Added fixed precision class, updated multi-tail calculations with fixed precision usage

  • #5368 – An error appears in the Console, when dragging a bond between any monomers

  • #4212 – Limit size of structures in preview

  • #5473 – Export of different mixed and alternatives RNAs (with different proportions and percents) works wrong

  • #5465 – Export of different mixed monomers (with different ratios) works wrong

  • #5512 – System saves mixture ambiguous monomers as alternatives ambiguous monomers

  • #5519 – Alias labels for mixed bases loaded from IDT are wrong

  • #5521 – Sugar color is wrong if loaded from HELM with inline SMILES

  • #5545 – After uploading a multi-character monomer in HELM format, abbreviations in sequence mode are cluttered together